腺苷（腺嘌呤核苷）是一种普遍存在的内源性 autacoid，通过四种 G 蛋白偶联受体 A1、A2A、A2B 和 A3 的登记发挥作用。
| Cas No. | 58-61-7 |
| 别名 | 腺苷; Adenine riboside; D-Adenosine |
| 化学名 | (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
| Canonical SMILES | C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)CO)O)O |
| 分子式 | C10H13N5O4 |
| 分子量 | 267.24 |
| 溶解度 | ≥ 12.75mg/mL in DMSO with gentle warming |
| 储存条件 | Store at 2-8°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.Target: Nucleoside antimetabolite/analogAdenosine plays an important role in biochemical processes, such as energy transfer — as adenosine triphosphate (ATP) and adenosine diphosphate (ADP) — as well as in signal transduction as cyclic adenosine monophosphate, cAMP. It is also an inhibitory neurotransmitter, believed to play a role in promoting sleep and suppressing arousal. Adenosine also plays a role in regulation of blood flow to various organs through vasodilation.Adenosine is an endogenous purine nucleoside that modulates many physiological processes. Cellular signaling by adenosine occurs through four known adenosine receptor subtypes. Extracellular adenosine concentrations from normal cells are approximately 300 nM; however, in response to cellular damage (e.g. in inflammatory or ischemic tissue), these concentrations are quickly elevated (600–1,200 nM). Thus, in regard to stress or injury, the function of adenosine is primarily that of cytoprotection preventing tissue damage during instances of hypoxia, ischemia, and seizure activity. Activation of A2A receptors produces a constellation of responses that in general can be classified as anti-inflammatory. References:
[1]. Sato A, et al. Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1633-40.
[2]. Costa F, et al. Role of nitric oxide in adenosine-induced vasodilation in humans. Hypertension. 1998 May;31(5):1061-4. |
