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LIT-001
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
LIT-001图片
CAS NO:2245072-21-1

LIT-001 是第一种非肽类催产素受体 (OT-R) 激动剂 (EC50=55 nM; Ki=226 nM)。LIT-001 改善孤独症小鼠模型的社交互动。
Cas No.2245072-21-1
Canonical SMILESO=C(N1[C@H](C(N(C)C)=S)CCC1)NCC2=CC=C(C(N3C4=CC=CC=C4NC(N(C)N=C5)=C5C3)=O)C=C2C.O=C(O)C(F)(F)F
分子式C30H34F3N7O4S
分子量645.7
溶解度DMSO: 250 mg/mL (387.18 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 improves social interaction in a mouse model of autism[1].

In vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only[1].

LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )[1]. Animal Model: Oprm1-/- mice (bred in house on a 50% 129SVPas-50% C57BL/6J hybrid background)[1]

[1]. Frantz MC, et al. LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism. J Med Chem. 2018 Oct 11;61(19):8670-8692.

 
 
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