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(2R,3S)-E1R
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(2R,3S)-E1R图片
CAS NO:1424832-60-9

(2R,3S)-E1R (Compound 2c) 是 E1R 的一种对映异构体。(2R,3S)-E1R 是 sigma-1 受体的正变构调节剂 (Sig1R PAM)，可用于治疗认知和记忆障碍。
Cas No.1424832-60-9
Canonical SMILESO=C(N)CN1[C@H](C)[C@H](C2=CC=CC=C2)CC1=O
分子式C13H16N2O2
分子量232.28
溶解度DMSO: 250 mg/mL (1076.29 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].

Sigma-1 receptor plays an important role in neuronal plasticity, a process implicated in the pathophysiology of neuropsychiatric diseases, such as Alzheimer's disease, major depressive disorders, and schizophrenia[1].

[1]. Veinberg G, et al. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21(10):2764-71.

 
 
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