MM 11253 是一种有效的选择性 RARγ 拮抗剂，IC50 为 44 nM。 MM 11253 对 RARα、RARβ 和 RXRα 的抑制作用较低。 MM 11253 阻断 RARγ 选择性激动剂的生长抑制作用。
| Cas No. | 345952-44-5 |
| 化学名 | 6-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dithiolan-2-yl)-2-naphthoic acid |
| Canonical SMILES | OC(C1=CC2=CC=C(C=C2C=C1)C3(C4=CC=C5C(C)(C)CCC(C)(C)C5=C4)SCCS3)=O |
| 分子式 | C28H30O2S2 |
| 分子量 | 462.67 |
| 溶解度 | 30 mg/ml in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MM-11253 is a synthetic, conformationally restricted retinoid that acts as a selective antagonist of retinoic acid receptor γ (RARγ).1 It dose-dependently blocks the ability of RARγ-selective agonists, but not retinoic acid (all-trans retinoic acid; to inhibit the growth of oral squamous cell carcinoma cells in vitro.[1] Reference:
[1]. Le, Q.T., Dawson, M.I., Soprano, D.R., et al. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene 19(11), 1457-1465 (2000). |
