An excitatory neurotransmitter
| Cas No. | 7558-63-6 |
| 别名 | 谷氨酸一铵 |
| Canonical SMILES | OC([C@@H](N)CCC(O)=O)=O.N |
| 分子式 | C5H9NO4.NH3 |
| 分子量 | 164.2 |
| 溶解度 | PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | L-Glutamic acid is a non-essential amino acid and the primary excitatory neurotransmitter in the CNS.1It acts on ionotropic and metabotropic receptors to induce excitatory synaptic transmission and has roles in synaptic plasticity. Excessive release of L-glutamic acid induces excitotoxicity that is associated with various human diseases, including amyotrophic lateral sclerosis (ALS), stroke, Parkinson's disease, Alzheimer's disease, and Huntington's disease.2Excessive L-glutamic acid release, in its protonated glutamate form, also occurs during seizure activity and contributes to epileptogenesis and seizure-induced brain damage.3 1.Garattini, S.Glutamic acid, twenty years laterJ. Nutr.130(4S Suppl)901S-909S(2000)
2.Greenamyre, J.T.The role of glutamate in neurotransmission and in neurologic diseaseArch. Neurol.43(10)1058-1063(1986)
3.Barker-Haliski, M., and White, H.S.Glutamatergic mechanisms associated with seizures and epilepsyCold Spring Harb. Perspect. Med.5(8)a022863(2015) |
