| CAS NO: | 1610802-47-5 |
| Cas No. | 1610802-47-5 |
| Canonical SMILES | O=C(N1)SC2=C1C=CC([C@H](C)C3=NN(C4=CC=C(OCCO)C=N4)C=C3)=C2 |
| 分子式 | C19H18N4O3S |
| 分子量 | 382.44 |
| 溶解度 | DMSO: 250 mg/mL (653.70 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | LY3130481 is an AMPA receptor antagonist that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, selective inhibits AMPA/TARP γ-8 with an IC50 of 65 nM[1]. IC50:65 nM (AMPA/TARP γ-8)[1] [1]. Gardinier KM,et al. Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8. J Med Chem. 2016 May 26;59(10):4753-68. |
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