EIPA hydrochloride (L593754 hydrochloride) 是一种 TRPP3 channel 抑制剂，其 IC50 值为 10.5 μM。EIPA 还抑制 Na+/H+ 交换器 (NHE) 和巨噬细胞。
| Cas No. | 1345839-28-2 |
| 别名 | L593754 hydrochloride; MH 12-43 hydrochloride |
| Canonical SMILES | O=C(C1=NC(Cl)=C(N(CC)C(C)C)N=C1N)NC(N)=N.Cl |
| 分子式 | C11H19Cl2N7O |
| 分子量 | 336.22 |
| 溶解度 | DMSO: 130 mg/mL (386.65 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM[1]. EIPA also inhibits Na+/H+-exchanger (NHE)[2] and macropinocytosis[3].
IC50: 10.5 μM (TRPP3 channel)[1]NHE[2]Macropinocytosis[3] [1]. Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85.
[2]. Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429.
[3]. Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis. |
