Barnidipine (Mepirodipine) 巴尼地平是一种 L 型钙拮抗剂 (CaA)，对 [3H] initrendipine 结合位点具有高亲和力 (Ki=0.21 nmol/l)，对 CaA 受体具有选择性作用。Barnidipine (Mepirodipine) 巴尼地平是一种抗高血压药物，通过减少其血管扩张作用继发的外周血管阻力起作用。
| Cas No. | 104713-75-9 |
| 别名 | 巴尼地平,Mepirodipine; YM-09730-5(Free base) |
| Canonical SMILES | O=C(C1=C(C)NC(C)=C(C(O[C@@H]2CN(CC3=CC=CC=C3)CC2)=O)[C@H]1C4=CC=CC([N+]([O-])=O)=C4)OC |
| 分子式 | C27H29N3O6 |
| 分子量 | 491.54 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors[1].Barnidipine (Mepirodipine) is an antihypertensive drug and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action[2].
Ki: 0.21 nmol/l ([3H] initrendipine)[1] [1]. van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8
[2]. Malhotra HS, et al. Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8. |
