熊去氧胆酸 (Ursodeoxycholate) 钠是肠道细菌转化 (cheno) 脱氧胆酸后产生的次级胆汁酸，是肠道屏障完整性的关键调节剂，对脂质代谢至关重要。
| Cas No. | 2898-95-5 |
| 别名 | 熊去氧胆酸钠盐; Ursodeoxycholate sodium; Ursodiol sodium; UCDA sodium |
| Canonical SMILES | [O-]C(CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=O.[Na+] |
| 分子式 | C24H39O4•Na |
| 分子量 | 414.6 |
| 溶解度 | DMF: 5 mg/ml,DMSO: 10 mg/ml,Ethanol: 15 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ursodeoxycholic acid (UDCA) is a secondary bile acid formed via epimerization of chenodeoxycholic acid . UDCA is also a metabolite of lithocholic acid in human liver microsomes. It inhibits taurocholic acid uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM. UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis. |
