A cyclic pentapeptolide antagonist of ET
Aand ET
B| Cas No. | 156223-08-4 |
| 别名 | 阿色拉星C |
| Canonical SMILES | O=C1O[C@@H]([C@@H](C(NCCC(N[C@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](CO)C(NC1)=O)=O)=O)=O)NC([C@@H](CCC(N)=O)NC(CCCCCCCC(C=CC=CCCCCC)=O)=O)=O)C |
| 分子式 | C46H66N8O11 |
| 分子量 | 907.1 |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Aselacin C is a cyclic pentapeptolide antagonist of endothelin receptor type A (ETA) and ETBoriginally isolated fromAcremonium.1It inhibits the binding of endothelin-1 to isolated bovine atrial membranes and porcine cerebral membranes, which endogenously express high levels of ETAand ETB, respectively, with IC50values of 60 and 80 µg/ml, respectively. 1.Jackson, M., Burres, N.S., Karwowski, J.P., et al.Aselacins, novel compounds that inhibit binding of endothelin to its receptor. I. The producing organism, fermentation and biological activityJ. Antibiot.47(5)523-527(1994) |
