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Azetidine-2-carboxylic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Azetidine-2-carboxylic acid图片
CAS NO:2517-04-6
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)询价
100mg询价

Azetidine-2-carboxylicacid是脯氨酸的非蛋白原氨基酸同系物。可以在常见的甜菜中找到。在许多物种(包括人类)中,它可以错误地掺入蛋白质中代替脯氨酸。致毒和致畸剂。
Cas No.2517-04-6
别名L-铃兰氨酸
Canonical SMILESO=C(O)C1NCC1
分子式C4H7NO2
分子量101.1
溶解度Water : 50 mg/mL (494.56 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent[1][2].

Azetidine-2-carboxylic acid (375-5oo μg per day) is incorporated into the collagen synthesized by chick embryo cartilage in vitro[3].

[1]. Rubenstein E, et al. Azetidine-2-carboxylic acid in the food chain. Phytochemistry. 2009 Jan;70(1):100-4. [2]. Rubenstein E, et al. Misincorporation of the proline analog azetidine-2-carboxylic acid in the pathogenesis of multiple sclerosis: a hypothesis. J Neuropathol Exp Neurol. 2008 Nov;67(11):1035-40. [3]. Lane JM, et al. Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. I. Arrest of collagen accumulation in growing chick embryos. Biochim Biophys Acta. 1971 Jun 29;236(3):517-27.

 
 
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