Carubicin is an anthracycline originally isolated from A. carminata that has anticancer activity.1,2 It is cytotoxic to MCF-7 and K562 cells (IC50s = 90 and 60 nM, respectively), as well as P-glycoprotein-expressing MCF-7/DOX and K562i/S9 cells (IC50s = 90 and 60 nM, respectively).1

|1. Tevyashova, A.N., Shtil, A.A., Olsufyeva, E.N., et al. Carminomycin, 14-hydroxycarminomycin and its novel carbohydrate derivatives potently kill human tumor cells and their multidrug resistant variants. J. Antibiot. (Tokyo) 57(2), 143-150 (2004).|2. Gause, G.F., Brazhnikova, M.G., and Shorin, V.A. A new antitumor antibiotic, carminomycin (NSC-180024). Cancer Chemother. Rep. 58(2), 255-256 (1974).