Zeylenone,可从 Uvaria grandiflora Roxb 的叶子的乙醇萃取物分离。Zeylenone 是一种天然存在的环己烯氧化物,通过 PI3K/AKT/mTOR 和 MAPK/ERK 信号通路抑制宫颈癌细胞增殖并诱导细胞凋亡 (apoptosis)。
Cas No. | 193410-84-3 |
别名 | 山椒子烯酮 |
Canonical SMILES | O=C1C=C[C@@H](OC(C2=CC=CC=C2)=O)[C@H](O)[C@]1(COC(C3=CC=CC=C3)=O)O |
分子式 | C21H18O7 |
分子量 | 382.36 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Zeylenone, isolated from ethanol extract of the leaves of Uvaria grandiflora Roxb. Zeylenone, a naturally occurring cyclohexene oxide, inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways[1]. [1]. Zhang L, et al. Zeylenone, a naturally occurring cyclohexene oxide, inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways. Sci Rep. 2017 May 10;7(1):1669. |