Targapremir-210是有效的miR-210抑制剂，作用于MDA-MB-231细胞系的IC50值为200nM。Targapremir-210通过和miR-210的发夹前体结构结合，进而抑制miRNA的成熟。
| Cas No. | 1049722-30-6 |
| 别名 | TGP-210 |
| Canonical SMILES | O=C(NCCCN=[N+]=[N-])CCCOC1=CC=CC(C2=NC3=CC=C(C4=NC5=CC=C(N6CCN(C)CC6)C=C5N4)C=C3N2)=C1 |
| 分子式 | C32H36N10O2 |
| 分子量 | 592.69 |
| 溶解度 | DMSO: 250 mg/mL (421.81 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Targapremir-210 is a potent miR-210 inhibitor with an IC50 of 200 nM in MDA-MB-231 cells. Targapremir-210 binds to the Dicer site of the miR-210 hairpin precursor. This interaction inhibits production of the mature miRNA. [1]. Costales MG, et al. Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit. J Am Chem Soc. 2017 Mar 8; 139(9):3446-3455. |
