位置:首页 > 产品库 > ABBV-744
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
ABBV-744
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ABBV-744图片
CAS NO:2138861-99-9
包装与价格:
包装价格(元)
5mg询价
10mg询价
25mg询价
50mg询价

ABBV-744 是一流的、具有口服活性和选择性的 BET 家族蛋白 BDII 结构域抑制剂,对 BRD2、BRD3、BRD4 和 BRDT 的 IC50 值范围为 4 至 18 nM。
Cas No.2138861-99-9
化学名N-ethyl-4-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide
Canonical SMILESO=C(C(N1)=CC(C(C2=CC(C(C)(O)C)=CC=C2OC3=C(C)C=C(F)C=C3C)=CN4C)=C1C4=O)NCC
分子式C28H30FN3O4
分子量491.5634
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ABBV-744 is a BDII-selective BET bromodomain inhibitor that is being investigated to treat AML and metastic castration-resistant prostate cancer.

Reference

[1]. FIDANZE, Steven D., et al. BROMODOMAIN INHIBITORS. WO 2017177955 A1.

 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024