HDAC-IN-4 是一种有效的、选择性的和具有口服活性的 I 类 HDAC 抑制剂，对 HDAC1、HDAC2 和 HDAC3 的 IC50 分别为 63 nM、570 nM 和 550 nM。 HDAC-IN-4 对 HDAC II 类没有活性。 HDAC-IN-4 具有抗肿瘤活性。
| Cas No. | 934828-12-3 |
| Canonical SMILES | O=C(NC1=C(N)C=CC=C1)C2=CC=C(C3CCN(CC4=CN(C)N=C4C)CC3)C=C2 |
| 分子式 | C24H29N5O |
| 分子量 | 403.52 |
| 溶解度 | DMSO : ≥ 31 mg/mL (76.82 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CXD101 is a class I-selective HDAC inhibitor (HDAC1 (IC50, 63 nM), HDAC2 (IC50, 570 nM), HDAC3 (IC50, 550 nM). CXD101 has no activity against HDAC class II[1]. References:
[1]. Eyre TA, et al. Predictive biomarkers for disease sensitivity in lymphoma - the holy grail for HDAC inhibitors Oncotarget. 2018 Dec 18;9(99):37280-37281. |
