A6770 是一种具有口服活性的强效 1-磷酸鞘氨醇 (S1P) 裂解酶 (S1PL) 抑制剂。
| Cas No. | 1331754-16-5 |
| Canonical SMILES | OCC1=CN=C(C(C)=O)N1 |
| 分子式 | C6H8N2O2 |
| 分子量 | 140.1 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50=<0.01 µM), an effect that is reduced in the presence of vitamin B6(EC50=<100 µM). 1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016) |
