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1,3,7-Trimethyluric Acid-d9
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
1,3,7-Trimethyluric Acid-d9图片
CAS NO:117490-42-3
包装与价格：
包装价格(元)
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An internal standard for the quantification of 1,3,7-trimethyluric acid
Cas No.117490-42-3
Canonical SMILESO=C(N(C1=O)C([2H])([2H])[2H])C(N(C(N2)=O)C([2H])([2H])[2H])=C2N1C([2H])([2H])[2H]
分子式C8HD9N4O3
分子量219.2
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1,3,7-Trimethyluric acid-d9is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine .1It is formed from caffeine by the cytochrome P450 (CYP) isoform CYP3A4. 1,3,7-Trimethyluric acid (500 µM) scavenges hydroxyl radicals in a cell-free assay and inhibitst-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes.2

1.Tassaneeyakul, W., Birkett, D.J., McManus, M.E., et al.Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoformsBiochem. Pharmacol.47(10)1767-1776(1994) 2.Bhat, V.B., Sridhar, G.R., and Madyastha, K.M.Efficient scavenging of hydroxyl radicals and inhibition of lipid peroxidation by novel analogues of 1,3,7-trimethyluric acidLife Sci.70(4)381-393(2001)

 
 
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