An inactive control for DO264
| Cas No. | 2301865-01-8 |
| Canonical SMILES | S=C(N[C@@H]1CN(C2=NC=CC(OC3=C(Cl)C=C(OC(F)(F)F)C=C3)=C2Cl)CCC1)NC4=CC=CN=C4 |
| 分子式 | C23H20Cl2F3N5O2S |
| 分子量 | 558.4 |
| 溶解度 | DMSO: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (S)-DO271 is an inactive control for the α/β-hydrolase domain-containing protein 12 (ABHD12) inhibitor DO264 .1,2Unlike DO264, (S)-DO271 does not inhibit ABHD12-dependent hydrolysis of lysophosphatidylserine (lyso-PS) in mouse brain membrane lysates when used at a concentration of 1 µM or modify inflammatory cytokine production in M1-polarized THP-1 macrophages. 1.Ogasawara, D., Ichu, T.-A., Vartabedian, V.F., et al.Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivoNat. Chem. Biol.14(12)1099-1108(2018)
2.Ogasawara, D., Ichu, T.-A., Jing, H., et al.Discovery and optimization of selective and in vivo active inhibitors of the lysophosphatidylserine lipase α/β-hydrolase domain-containing 12 (ABHD12)J. Med. Chem.62(3)1643-1656(2019) |
