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Neoruscogenin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Neoruscogenin图片
CAS NO:17676-33-4
包装与价格：
包装价格(元)
5mg询价
10mg询价
20mg询价

Neoruscogenin 是甾体皂苷元家族的成员，是核受体 RORα (NR1F1) 的生物可利用、有效和高亲和力的激动剂。
Cas No.17676-33-4
别名新鲁斯可皂苷元
化学名spirosta-5,25(27)-diene-1β,3β-diol
Canonical SMILESC=C(CO1)CC[C@@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)C[C@@H](O)[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C
分子式C27H40O4
分子量428.6
溶解度≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Neoruscogenin is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα [1]. Neoruscogenin is a natural sapogenin extracted from Butcher’s broom (Rusci rhizoma, Ruscus aculeatus, Ruscaceae) [2].

RAR-related orphan receptor alpha (RORα) is a nuclear receptor that participates in the transcriptional regulation of some genes involved incircadian rhythm. Genetic studies have revealed that RORα plays an important role in the development of the central nervous system and has been associated with genetic lesions in mice [3].

In vitro: In confluent human microvascular endothelial cells (HMEC-1), pre-treatment with neoruscogenin slightly decreased the permeability at concentrations up to 100 μM (71.8%). The EC50 of neoruscogenin against the nuclear receptor RORα was 110 nM [1].

In vivo: In mice, oral administration of neoruscogenin (3 mg/kg/d) for seven days up-regulated the expression of several RORα-inducible genes in the liver [1].

References:
[1] Helleboid S, Haug C, Lamottke K, et al.  The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1)[J]. Journal of biomolecular screening, 2013: 1087057113497095.
[2] Barbi M, Willer E A, Rothenhfer M, et al.  Spirostanol saponins and esculin from Rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells[J]. Phytochemistry, 2013, 90: 106-113.
[3] Giguère V.  Orphan nuclear receptors: from gene to function 1[J]. Endocrine reviews, 1999, 20(5): 689-725.

 
 
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