首页 蛋白库 基因库 产品 会员服务
位置：首页 > 产品库 > DL-Folinic Acid(calcium salt)
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
DL-Folinic Acid(calcium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DL-Folinic Acid(calcium salt)图片
CAS NO:1492-18-8
包装与价格：
包装价格(元)
100mg询价
500mg询价

DL-叶酸（钙盐）（亚叶酸钙）是一种生物叶酸，通常与甲氨蝶呤 (MTX) 一起作为救援剂使用，以降低 MTX 诱导的毒性。
Cas No.1492-18-8
别名亚叶酸钙; Leucovorin calcium; Calcium folinate
化学名N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, monocalcium salt
Canonical SMILESO=CN1C(CNC2=CC=C(C(N[C@H](C([O-])=O)CCC([O-])=O)=O)C=C2)CNC3=C1C(N=C(N)N3)=O.[Ca+2]
分子式C20H21N7O7o Ca
分子量511.5
溶解度Water: 0.3 mg/ml
储存条件4°C, protect from light ,unstable in solution, ready to use.
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].

MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) [1].

Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].

References:
[1]. Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397(2):221-8.
[2]. Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.

 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024