Mertansine (DM1) 是一种微管蛋白抑制剂，是一种可偶联抗体的类美登素，旨在克服与美登素相关的全身毒性并增强肿瘤特异性递送。 Mertansine 可以通过接头连接到单克隆抗体上，以产生抗体-药物偶联物 (ADC)。
| Cas No. | 139504-50-0 |
| 别名 | 美登素,DM1; Maytansinoid DM1 |
| Canonical SMILES | C[C@]1([C@@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([C@H](C)N(C)C(CCS)=O)=O)[C@H]([C@@H]([C@](OC4=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N4)O)C)O1 |
| 分子式 | C35H48ClN3O10S |
| 分子量 | 738.29 |
| 溶解度 | DMSO : ≥ 83.33 mg/mL (112.87 mM);Water :< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at -20°C,unstable in solution, ready to use. |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. References:
[1]. Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules. |
