Leptomycin A 是一种链霉菌代谢物，是 CRM1（出口蛋白 1）的抑制剂，可阻断 CRM1 与核输出信号的相互作用，从而阻止多种蛋白质的核输出。
| Cas No. | 87081-36-5 |
| 别名 | 来普霉素A |
| 化学名 | (2E,6R)-19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5S,7S,9R,11,15R,17-heptamethyl-8-oxo-2,10E,12E,16Z,18E-nonadecapentaenoic acid |
| Canonical SMILES | O=C1O[C@@H](/C=C/C(C)=C\[C@H](C)C/C=C/C(C)=C/[C@H](C([C@H]([C@@H]([C@H](C/C(C)=C/C(O)=O)C)O)C)=O)C)[C@@H](C)C=C1 |
| 分子式 | C32H46O6 |
| 分子量 | 526.7 |
| 溶解度 | Ethanol: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B[1][2]. References:
[1]. Kudo, N., et al. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242(2), 540-547 (1998).
[2]. Wolff B, et al. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol. 1997 Feb;4(2):139-47. |
