首页 蛋白库 基因库 产品 会员服务
位置：首页 > 产品库 > SJB3-019A
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
SJB3-019A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SJB3-019A图片
CAS NO:2070015-29-9
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
2mg询价
5mg询价
10mg询价
50mg询价
100mg询价

SJB3-019A 是一种有效的新型 USP1 抑制剂，在促进 K562 细胞中 ID1 降解和细胞毒性方面的作用是 SJB2-043 的 5 倍，IC50 为 0.0781 μM。
Cas No.2070015-29-9
化学名2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione
Canonical SMILESO=C(C1=C2OC(C3=CN=CC=C3)=N1)C4=CC=CC=C4C2=O
分子式C16H8N2O3
分子量276.25
溶解度≥ 10.85mg/mL in DMSO with gentle warming
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SJB3-019A is a potent and novel inhibitor of USP1 with IC50 value of 0.0781 μM [1].

Ubiquitin-specific protease 1 (USP1) is a deubiquitinating (DUB) enzyme and removes polyubiquitin chains from the DNA binding 1 (ID1) protein, which plays an important role in the proliferation and progression of cancers, such as leukemia [1].

SJB3-019A is a potent and novel USP1 inhibitor. In K562 cells, SJB3-019A exhibited 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity. In HeLa cells, SJB3-019A increased the levels of Ub-PCNA and Ub-FANCD2 and reduced the homologous recombination activity [1].

Reference:
[1].  Mistry H, Hsieh G, Buhrlage SJ, et al. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther, 2013, 12(12): 2651-2662.

 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024