| CAS NO: | 2092923-21-0 |
| Cas No. | 2092923-21-0 |
| Canonical SMILES | O=C1C2=CC=CC=C2[C@]3(C4=CC=C(Cl)C(C)=C4)N1CCN3C(C5=CC(F)=C(F)C=C5)=O |
| 分子式 | C24H17ClF2N2O2 |
| 分子量 | 438.85 |
| 溶解度 | DMSO: 100 mg/mL (227.87 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. VU 6008667 has high CNS penetration[1]. [1]. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359. |
| 维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024 |