首页 蛋白库 基因库 产品 会员服务
位置：首页 > 产品库 > Racanisodamine
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Racanisodamine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Racanisodamine图片
CAS NO:17659-49-3

Racanisodamine 是 anisodamine 的一种消旋体，二者药理作用类似。Racanisodamine 是一种非选择性的 muscarinic 拮抗剂，为近视控制滴眼液的有效成分。

Cas No.17659-49-3
别名消旋山莨菪碱
化学名αS-(hydroxymethyl)-benzeneacetic acid, 6-hydroxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Canonical SMILESO=C(OC1CC(N2C)CC(O)C2C1)C(CO)C3=CC=CC=C3
分子式C17H23NO4
分子量305.37
溶解度25mg in ethanol or DMF, 20mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Anisodamine is a natural tropane alkaloid shown to be a weak antagonist of α1-adrenoceptors, blocking WB-4101 and clonidine binding in brain membrane preparations with pKi values of 2.63 and 1.61, respectively.[1] Anisodamine also has antioxidant effects that may protect against free radical-induced cellular damage.[2] Anisodamine is predominantly found in the roots of A. tanguticus, which is used in traditional Chinese medicine for topical applications.[3]

Reference:
[1]. Varma, D.R., and Yue, T.L. Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats. British Journal of Pharmacology 87(3), 587-594 (1986).
[2]. Poupko, J.M., Baskin, S.I., and Moore, E. The pharmacological properties of anisodamine. Journal of Applied Toxicology 27(2), 116-121 (2007).
[3]. Ma, L., Gu, R., Tang, L., et al. Important poisonous plants in tβ ethnomedicine. Toxins (Basel) 7(1), 138-155 (2015).

 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024