A tetrapeptide -opioid receptor agonist
| Cas No. | 2393866-13-0 |
| Canonical SMILES | O=C(N[C@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@H](CC1=CC=CC=C1)C(O)=O)=O)=O)[C@@H](N)CC2=CC=C(O)C=C2 |
| 分子式 | C28H38N4O6 |
| 分子量 | 526.6 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Bilaid C is a tetrapeptide µ-opioid receptor agonist (Ki= 210 nM in HEK293 cell membranes expressing the human receptor) that has been found inPenicillium.1It inhibits forskolin-induced cAMP accumulation by 77% in HEK293 cells expressing the human µ-opioid receptor when used at a concentration of 10 µM. Bilaid C induces inward rectifying potassium channel (Kir) currents in rat locus coeruleus slices that endogenously express high levels of the µ-opioid receptor (EC50= 4.2 µM). 1.Dekan, Z., Sianati, S., Yousuf, A., et al.A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptorProc. Natl. Acad. Sci. USA116(44)22353-22358(2019) |
