Brevetoxin B (Brevetoxin-2; PbTx-2) 是一种由卡列尼亚属和其他甲藻产生的聚酮类神经毒素。
| Cas No. | 79580-28-2 |
| 别名 | 短裸甲藻毒素2,Brevetoxin-2; PbTx-2 |
| Canonical SMILES | CC1=CC(OC2C1OC3(C)C(OC4C(OC5C(OC(CC(OC6(C)C(OC7C(OC(CC(OC(CC(C=O)=C)CC8O)C8(C)O9)C9C7)/C=C\C6)C%10)C%10(C)O%11)C%11(C)CC5)C(C)C4)C3)C2)=O |
| 分子式 | C50H70O14 |
| 分子量 | 895.1 |
| 溶解度 | Ethyl Acetate: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning. |
