Apoptolidin 是一种从诺卡氏菌属细菌中分离出来的聚酮化合物。 Apoptolidin 是一种选择性线粒体 F1FO ATPase 抑制剂。 Apoptolidin 是一种凋亡诱导剂，可在用包括 ElA 在内的 12 型腺病毒癌基因 (IC50=10-17 ng/ml) 转化的细胞中诱导凋亡细胞死亡，但在正常细胞中不诱导。
| Cas No. | 194874-06-1 |
| Canonical SMILES | O[C@H]([C@](OC(/C(C)=C/C(C)=C/C(C)=C/[C@@H](C)[C@H](O[C@@](O[C@@H](C)[C@H](OC)[C@H]1O)([H])[C@H]1O)/C=C/C(C)=C/CC2)=O)([H])C[C@@H]([C@H]2O)OC)[C@](O[C@@H]3C[C@H](COC)O[C@H](O[C@@H](C)[C@@H]4O[C@@](O[C@H](C)[C@H]5O)([H])C[C@H]5OC)C[C@@]4(O)C)([C@@H]([ |
| 分子式 | C58H96O21 |
| 分子量 | 1129.4 |
| 溶解度 | DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria. It inhibits the mitochondrial F1FO ATPase (Ki = 4-5 µM). Apoptolidin selectively kills transformed glial cells without significantly affecting untransformed cells. It also has antibiotic and antifungal actions. |
