Valnoctamide (Valmethamide) 是丙戊酸盐的衍生物，可抑制苯二氮卓类药物难治性癫痫持续状态。
| Cas No. | 4171-13-5 |
| 别名 | 戊诺酰胺,Valmethamide |
| Canonical SMILES | CCC(C(N)=O)C(C)CC |
| 分子式 | C8H17NO |
| 分子量 | 143.2 |
| 溶解度 | DMF: 16 mg/ml,DMSO: 30 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Valnoctamide is an isomer of the valproic acid amide, valpromide. It has been marketed as an anxiolytic and sedative compound and suppresses neuropathic pain. Unlike valpromide, valnoctamide is not metabolized to its acid form, valnoctic acid, in vivo and has no teratogenicity. It abolishes the activity of myo-inositol-1-phosphate synthase in human brain crude homogenates (Ki = 0.18 mM). Valnoctamide suppresses electrographic seizures in animal models of status epilepticus, suggesting potential applications in managing epilepsy. |
