Mal-PEG2-Val-Cit-amido-PAB-OH 是一种可降解 (cleavable) 的 ADC linker，用于抗体偶联药物 (ADCs) 的合成。 Mal-PEG2-Val-Cit-amido-PAB-OH 也可用作 PROTAC 的 Linker，可用于 PROTAC 的合成。
| Cas No. | 2055041-38-6 |
| 分子式 | C29H42N6O9 |
| 分子量 | 618.68 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Mal-PEG2-Val-Cit-amido-PAB-OH is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-Val-Cit-amido-PAB-OH also can be used as aPROTAC linkerthat can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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