Z-VAD-FMK(Caspase Inhibitor VI)

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CAS NO:	161401-82-7
规格:	≥98%

包装与价格：

理化性质和储存条件

Molecular Weight (MW)	453.46
Formula	C21H28FN3O7
CAS No.	161401-82-7
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 90 mg/mL (198.47 mM)
	Water:<1 mg/mL (slightly soluble or insoluble)
	Ethanol: N/A
SMILES	O=C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(CF)=O)=O)=O)C(C)C)OCC1=CC=CC=C1
Chemical Name	Z-VAD(OH)-FMK; Z-VAD FMK L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-

实验参考方法

In Vitro	Z-VAD(OH)-FMK is the non-methylated form of Z-VAD-FMK, and useful in studies including recombinant, or purified enzymes. As an irreversible general caspase inhibitor, it is useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I, this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 μl) solution of Caspase Inhibitor VI in DMSO is also available.
In Vivo	N/A
Animal model	N/A
Formulation & Dosage	N/A
References	Garcia-Calvo M, et al. J Biol Chem. 1998, 273(49), 32608-32613.

生物活性

Inhibition of caspases by tetrapeptide aldehydes. J Biol Chem. 1998 Dec 4;273(49):32608-13.

Inhibition of caspases by CrmA. J Biol Chem.1998 Dec 4;273(49):32608-13.