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Bergenin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Bergenin图片
CAS NO:477-90-7
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
20mg询价

卑尔根素是一种细胞保护和抗氧化多酚，存在于许多药用植物中。
Cas No.477-90-7
别名岩白菜素; Cuscutin
化学名(2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one
Canonical SMILESCOC1=C(C=C2C(=C1O)C3C(C(C(C(O3)CO)O)O)OC2=O)O
分子式C14H16O9
分子量328.27
溶解度≥ 14.55mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties[1][2].

Bergenin (7.5-30μM; 24 hours) decreases the viability of HeLa cervical cancer cells (IC50=15 μM)[1].Bergenin (7.5-30 μM; 24 hours) induces apoptosis in HeLa cervical cancer cells[1].

Pretreatment with Bergenin (12.5-100 mg/kg; i.p.; once) produces a dose-related inhibition of acetic acid-induced writhing in mice[3].

References:
[1]. Shi X, et al. Anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the STAT3 signalling pathway. Exp Ther Med. 2019 May;17(5):3525-3529.
[2]. Yun J, et al. Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice. Arch Pharm Res. 2015 Jun;38(6):1248-54.
[3]. de Oliveira CM, et al. Antinociceptive properties of bergenin. J Nat Prod. 2011 Oct 28;74(10):2062-8.

 
 
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