Boldine 是一种从山苍子根中提取的阿朴啡异喹啉生物碱，还具有这些特性，包括抗氧化、抗炎和细胞保护作用。
| Cas No. | 476-70-0 |
| 别名 | 波尔定 |
| Canonical SMILES | OC1=C(OC)C2=C3[C@](N(C)CCC3=C1)([H])CC4=CC(O)=C(OC)C=C42 |
| 分子式 | C19H21NO4 |
| 分子量 | 327.4 |
| 溶解度 | DMF: 50 mg/mL,DMSO: 50 mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL,Ethanol: 30 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis[1]. References:
[1]. Zhao H , et al. Boldine isolated from Litsea cubeba inhibits bone resorption by suppressing the osteoclast differentiation in collagen-induced arthritis. Int Immunopharmacol. 2017 Oct;51:114-123. |
