Spastazoline 是一种有效、选择性的 spastin (一种微管切断 AAA 蛋白) 抑制剂，对人 spastin 的 IC50 值为 99 nM。Spastazoline 对重组人 VPS4 的 ATPase 活性没有作用。
| Cas No. | 2351882-11-4 |
| 分子式 | C20H30N8 |
| 分子量 | 382.51 |
| 溶解度 | DMSO : 100 mg/mL (261.43 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Spastazoline is a potent and selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC50 of 99 nM for Human spastin. Spastazoline shows no effect on ATPase activity of a recombinant human VPS4[1]. [1]. Cupido T, et al. Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Nat Chem Biol. 2019 Feb 18. |
