Sulazepam 是一种苯二氮卓类药物，是一种选择性卵巢癌 G 蛋白偶联受体 (OGR1) 激动剂。Sulazepam 具有抗惊厥作用，也有用于气道高反应性 (AHR) 研究的潜力。
| Cas No. | 2898-13-7 |
| 别名 | 硫西泮 |
| 分子式 | C16H13ClN2S |
| 分子量 | 300.81 |
| 溶解度 | DMSO : 50 mg/mL (166.22 mM; ultrasonic and warming and heat to 60°C) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Sulazepam, a benzodiazepine, is a selective ovarian cancer G protein-coupled receptor (OGR1) agonist. Sulazepam has anticonvulsive action and has the potential for airway hyperresponsiveness (AHR) research[1][2]. Sulazepam (3.2 mg/kg in 25 µL via intranasal route ∼30 min before HDM challenge; 5 days a week for three consecutive weeks) inhibits the development of airway hyperresponsiveness (AHR) in Male and female wild-type C57BL/6 mice (8-10 wk old), but not in age-matched OGR1KO mice (C57BL/6 background) with house dust mite (HDM) allergen (25 μg; intranasally)[1]. |
