TDRL-551 是一种有效的复制蛋白A (RPA) 抑制剂 (IC50=18 ?M)。TDRL-551 抑制 RPA-DNA 相互作用，提高以铂为基础的肺癌和卵巢癌化疗的疗效。RPA 在核苷酸切除修复 (NER) 和同源重组 (HR) 中起着至关重要的作用，在 DNA 复制和 DNA 损伤检查点激活中也起着重要作用。
| Cas No. | 1644626-43-6 |
| 分子式 | C25H23ClIN3O4 |
| 分子量 | 591.83 |
| 溶解度 | DMSO : 62.5 mg/mL (105.60 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 µM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1]. [1]. Mishra AK, et al. Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer. Biochem Pharmacol. 2015;93(1):25-33. |
