| CAS NO: | 2242480-48-2 |
| 包装 | 价格(元) |
| 5mg | 询价 |
| 10mg | 询价 |
| 25mg | 询价 |
| 50mg | 询价 |
| Cas No. | 2242480-48-2 |
| 分子式 | C15H17N3O3S |
| 分子量 | 319.38 |
| 溶解度 | DMSO : 62.5 mg/mL (195.69 mM; Need ultrasonic) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity[1]. VPC-18005 is found to inhibit pETS-luc reporter activity in PNT1B-ERG and VCaP cells with IC50 values of 3 and 6 μM, respectively[1].VPC-18005 could suppress ERG reporter activity without exhibiting overt cytotoxicity[1].VPC-18005 inhibits migration and invasion of ERG-overexpressing cells in vitro[1].VPC-18005 can antagonize the metastatic potential of ERG-expressing prostate cells[1].The exposure of larvae to 1 or 10 µM of VPC-18005 produced a 20-30% decrease in the dissemination of cancer cells in zebrafsh[2]. [1]. Miriam S Butler, et al. Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer. Oncotarget. 2017 Jun 27;8(26):42438-42454. |
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