Thalidomide(Immunoprin,Contergan and Thalomid)

Molecular Weight (MW)	258.23
Formula	C13H10N2O4
CAS No.	50-35-1
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 52 mg/mL (201.37 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: 2 mg/mL (7.74 mM)
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% Propylene glycol: 5 mg/mL
Chemical Name	Chemical Name: 2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione InChi Key: UEJJHQNACJXSKW-UHFFFAOYSA-N InChi Code: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17) SMILES Code: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3)=O
Synonyms	Brand names: Synovir; Thalomid (US); Foreign brand names: Contergan; Distaval; Kevadon; Neurosedyn; Pantosediv; Sedoval K17; Softenon Talimol; alphaphthalimidoglutarimide. Nphthaloylglutamimide; Nphthalylglutamic acid imide.

Molecular Weight (MW)

258.23

Formula

C13H10N2O4

CAS No.

50-35-1

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 52 mg/mL (201.37 mM)

Water:<1 mg/mL (slightly soluble or insoluble)

Ethanol: 2 mg/mL (7.74 mM)

Solubility (In vivo)

30% PEG400+0.5% Tween80+5% Propylene glycol: 5 mg/mL

Chemical Name

Chemical Name: 2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

InChi Key: UEJJHQNACJXSKW-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)

SMILES Code: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3)=O

Synonyms

Brand names: Synovir; Thalomid (US); Foreign brand names: Contergan; Distaval; Kevadon; Neurosedyn; Pantosediv; Sedoval K17; Softenon Talimol; alphaphthalimidoglutarimide. Nphthaloylglutamimide; Nphthalylglutamic acid imide.

In Vitro	Thalidomide must be metabolized by the liver to form an epoxide that may be the active teratogenic metabolite. Thalidomide selectively inhibits the production of human monocyte tumor necrosis factor alpha (TNF-alpha) when human monocytes are triggered with lipopolysaccharide and other agonists in culture.
In Vivo	Thalidomide (100 mg/kg, p.o.) inhibits the collagen deposition, down-regulates the mRNA expression level of α-SMA and collagen I, and significantly reduces the pro-inflammatory cytokines in RILF mice. Thalidomide alleviates RILF via suppression of ROS and down-regulation of TGF-β/Smad pathway dependent on Nrf2 status. Thalidomide (200 mg/kg, p.o.) combined with icotinib shows synergistic anti-tumor effects in nude mice bearing PC9 cells, suppressing tumor growth and promoting tumor death.
Animal model	C57BL/6 mice
Formulation & Dosage	100 mg/kg, p.o.
References	[1] D Amato RJ, et al. Proc Natl Acad Sci U S A, 1994, 91(9), 4082-4085. ; Free Radic Biol Med. 2018 Dec;129:446-453.

In Vitro

Thalidomide must be metabolized by the liver to form an epoxide that may be the active teratogenic metabolite. Thalidomide selectively inhibits the production of human monocyte tumor necrosis factor alpha (TNF-alpha) when human monocytes are triggered with lipopolysaccharide and other agonists in culture.

In Vivo

Thalidomide (100 mg/kg, p.o.) inhibits the collagen deposition, down-regulates the mRNA expression level of α-SMA and collagen I, and significantly reduces the pro-inflammatory cytokines in RILF mice. Thalidomide alleviates RILF via suppression of ROS and down-regulation of TGF-β/Smad pathway dependent on Nrf2 status. Thalidomide (200 mg/kg, p.o.) combined with icotinib shows synergistic anti-tumor effects in nude mice bearing PC9 cells, suppressing tumor growth and promoting tumor death.

Animal model

C57BL/6 mice

Formulation & Dosage

100 mg/kg, p.o.

References

[1] D Amato RJ, et al. Proc Natl Acad Sci U S A, 1994, 91(9), 4082-4085. ; Free Radic Biol Med. 2018 Dec;129:446-453.

CAS NO:	50-35-1
规格:	≥98%

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