(S)-Indoximod(1-Methyl-L-tryptophan)是吲哚胺-2,3-双加氧酶(IDO)抑制剂。(S)-Indoximod可用于癌症研究。
| Cas No. | 21339-55-9 |
| 别名 | 相思子碱,1-Methyl-L-tryptophan; (S)-NLG-8189 |
| Canonical SMILES | N[C@@H](CC1=CN(C)C2=CC=CC=C12)C(O)=O |
| 分子式 | C12H14N2O2 |
| 分子量 | 218.25 |
| 溶解度 | DMSO: 5 mg/mL (22.91 mM; ultrasonic and adjust pH to 5 with HCl) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2]. [1]. Huang GL, et, al. PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel). 2019 May 9;9(5):719.
[2]. Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143(6):1516-1529. |
