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(3S,5R)-Fluvastatin sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(3S,5R)-Fluvastatin sodium图片
CAS NO:94061-81-1
包装:5mg
市场价:4950元

(3S,5R)-Fluvastatinsodium((3S,5R)-XU62-320)是Fluvastatin的(3S,5R)对映体。Fluvastatin是第一个完全合成的,竞争性的HMG-CoAreductase还原酶抑制剂,IC50为8nM。Fluvastatin通过依赖Nrf2的抗氧化通路保护血管平滑肌细胞免受氧化应激。
Cas No.94061-81-1
别名(3S,5R)氟伐他汀钠盐,(3S,5R)-XU 62-320
Canonical SMILESFC1=CC=C(C2=C(/C=C/[C@H](O)C[C@H](O)CC(O[Na])=O)N(C(C)C)C3=C2C=CC=C3)C=C1
分子式C24H25FNNaO4
分子量433.45
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].

[1]. AraÚjo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24.

 
 
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