TNO155 是一种有效的选择性和口服活性的野生型 SHP2 变构抑制剂 (IC50=0.011 μM)。 TNO155 具有研究 RTK 依赖性恶性肿瘤，尤其是晚期实体瘤的潜力。
| Cas No. | 1801765-04-7 |
| 别名 | (3S,4S)-8-(6-氨基-5-((2-氨基-3-氯吡啶基-4-基)硫代)吡嗪-2-基)-3-甲基-2-氧杂-8-氮杂螺[4.5]癸-4-胺,TNO155 |
| Canonical SMILES | N[C@@H]1[C@H](C)OCC12CCN(C3=NC(N)=C(SC4=C(Cl)C(N)=NC=C4)N=C3)CC2 |
| 分子式 | C18H24ClN7OS |
| 分子量 | 421.95 |
| 溶解度 | DMSO: 250 mg/mL (592.49 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors[1]. [1]. TNO155: SHP2 inhibitor |
