AMP-PCP disodium 是一种 ATP 类似物，可以以 Kd 值 为 3.8 μM 来结合到 Hsp90 的 N 末端结构域。AMP-PCP disodium 结合有利于 Hsp90 活性同型二聚体的形成。
| Cas No. | 7414-56-4 |
| Canonical SMILES | O[C@H]1[C@@H](O[C@H](COP(OP(CP(O)(O[Na])=O)(O[Na])=O)(O)=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2 |
| 分子式 | C11H16N5Na2O12P3 |
| 分子量 | 549.17 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90[1]. [1]. Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542. |
