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T2AA
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
T2AA图片
CAS NO:1380782-27-3
包装与价格：
包装价格(元)
10mg询价
50mg询价

PCNA inhibitor
Cas No.1380782-27-3
Canonical SMILESIC1=C(OC2=CC=C(O)C=C2)C(I)=CC(C[C@H](N)CO)=C1
分子式C15H15I2NO3
分子量511.09
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50 ~1 μM). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Suppresses cancer cell growth.

Punchihewa et al (2012) Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J.Biol.Chem. 287 14289 PMID:22383522

 
 
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