ENPP1 Inhibitor C (Compound C) 是一种有效的 ENPP1（外核苷酸焦磷酸酶/磷酸二酯酶 1）抑制剂，IC50 值为 0.26、0.48 和 2.0 μM 分别通过 TG-mAMP、pNP-TMP 和 ATP 测定法评估。 TG (Tokyo Green)-mAMP:一种新合成的灵敏 ENPP1 荧光探针。
| Cas No. | 2378640-92-5 |
| Canonical SMILES | NC1=CC=CC(CC2=C(N(C)C)N3C(N=C2C)=NC=N3)=C1 |
| 分子式 | C15H18N6 |
| 分子量 | 282.3 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ENPP1 inhibitor C is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50 = 0.26 μM in a cell-free assay).1 It is selective for ENPP1 over ENPP2-7 at 10 μM. ENPP1 inhibitor C decreases ENPP1 activity in MDA-MB-231 human breast and C6 rat glioma cancer cells when used at a concentration of 10 μM. |1. Kawaguchi, M., Han, X., Hisada, T., et al. Development of an ENPP1 fluorescence probe for inhibitor screening, cellular imaging, and prognostic assessment of malignant breast cancer. J. Med. Chem. 62(20), 9254-9269 (2019). |
