| 产品描述 | Ro 08-2750 is a p75 neurotrophin receptor (p75NTR) ligand that completely inhibits nerve growth factor (NGF) binding to p75NTRin PC12 cells when used at a concentration of 100 μM.[1] It also binds to NGF dimers (Kd = ~1 μM) to induce a conformational change that prevents NGF binding to p75NTRor tropomyosin-related kinase A (TrkA). Ro 08-2750 inhibits NGF-induced death of SK-N-MC cells and inhibits autophosphorylation of TrkA in PC12 cells. It reverses NGF-induced decreases in β-catenin mRNA expression in, and migration of, SKOV3 and OVCAR-3 ovarian cancer cells.[2] Reference:
[1]. Niederhauser, O., Mangold, M., Schubenel, R., et al. NGF ligand alters NGF signaling via p75NTR and trkA. J. Neurosci. Res. 61(3), 263-272 (2000).
[2]. Li, B., Cai, S., Zhao, Y., et al. Nerve growth factor modulates the tumor cells migration in ovarian cancer through the WNT/β-catenin pathway. Oncotarget 7(49), 81026-81048 (2016). |
