PF 06465469 是 ITK 的共价抑制剂，IC50 为 2 nM。
| Cas No. | 1407966-77-1 |
| 化学名 | (R)-3-(1-(1-acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropyl-3-methylphenyl)benzamide |
| Canonical SMILES | C=CC(N1CCC[C@](N2C3=NC=NC(N)=C3C(C4=CC(C(NC(C=C5C)=CC=C5C(C)C)=O)=CC=C4)=N2)([H])C1)=O |
| 分子式 | C30H33N7O2 |
| 分子量 | 523.63 |
| 溶解度 | <2.62mg/ml in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM[1]. References:
[1]. Mamand S, et al. Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma. Sci Rep. 2018 Sep 21;8(1):14216. |
