| CAS NO: | 38183-03-8 |
| Cas No. | 38183-03-8 |
| 别名 | 7,8-二羟基黄酮 |
| 化学名 | 7,8-dihydroxy-2-phenyl-4H-chromen-4-one |
| Canonical SMILES | OC1=C(C2=CC=C1O)OC(C3=CC=CC=C3)=CC2=O |
| 分子式 | C15H10O4 |
| 分子量 | 254.24 |
| 溶解度 | ≥ 12.75mg/mL in DMSO |
| 储存条件 | Store at 4°C, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1]. 7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis[1]. 7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease[1]. Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease[2]. References: |
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