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Tyrphostin 9
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tyrphostin 9图片
CAS NO:10537-47-0
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
25mg询价
50mg询价

Tyrphostin 9 是一种 PDGFR 抑制剂，是线粒体裂变的有效诱导剂。
Cas No.10537-47-0
别名酪氨酸磷酸化抑制剂A9,Tyrphostin 9; Malonoben
化学名2-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile
Canonical SMILESCC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N
分子式C18H22N2O
分子量282.38
溶解度≥ 14.1mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tyrphostin 9 is an inhibitor of PDGFR with IC50 value of ~2.5μM [1].

Tyrphostin 9 is generated as specific inhibitor of PDGFR in 1991. It also has inhibitory effect on the proliferation of SMC. Tyrphostin 9 potently inhibits the PDGF-dependent SMC proliferation with IC50 value of 40nM and inhibits the PDGF-dependent autophosphorylation of PDGFR with IC50 value of ~2.5μM. Besides that, Tyrphostin 9 also affects the phosphorylation of PLCγ (IC50 value of about 2.5μM) and the PDGF-dependent c-fos expression. Moreover, Tyrphostin 9 is found to be an inhibitor of EGFR with IC50 value of 460μM [1, 2].

In the rat carotid artery injury model, treatment of Tyrphostin 9 significantly reduces neointimal hyperplasia through inhibiting the tyrosine phosphorylation in injured arteries [1].

References:
[1] Levitzki A. PDGF receptor kinase inhibitors for the treatment of restenosis. Cardiovascular research, 2005, 65(3): 581-586.
[2] Levitzki A. Tyrphostins—potential antiproliferative agents and novel molecular tools. Biochemical pharmacology, 1990, 40(5): 913-918.

 
 
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