TMPyP4 tosylate (TMP 1363) 是一种四链体特异性配体，可抑制 G-四链体与 IGF-1 之间的相互作用。 TMPyP4 tosylate (TMP 1363) 是一种端粒酶抑制剂，在骨肉瘤细胞系中具有抗肿瘤作用。
| Cas No. | 36951-72-1 |
| 别名 | TMPYP[=Α,Β,Γ,Δ-四(1-甲基吡啶嗡-4-基)卟吩对甲苯磺酸盐][铜和镁用超高灵敏分光光度试剂][用于以高效液相色谱金属同时测定],TMP 1363 |
| 分子式 | C72H66N8O12S4 |
| 分子量 | 1363.6 |
| 溶解度 | ≥ 55.6mg/mL in Water |
| 储存条件 | Store at 2-8°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand, which inhibits the interaction between G-quadruplexes and IGF-1[1]. TMPyP4 tosylate (TMP 1363) is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines[2]. References:
[1]. Chen H, et al. Insuline-like growth factor type I selectively binds to G-quadruplex structures. Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):31-38.
[2]. Fujimori J, et al. Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines. J Orthop Res. 2011 Nov;29(11):1707-11. |
